Withdrawal of Mixtard 30
Nearest equivalent insulin to Mixtard 30
Mixtard 30 is human premixed insulin 30% of which is short-acting insulin and 70% is intermediate-acting, isophane insulin.
Humulin M3 is the nearest equivalent insulin to Mixtard 30. It is made by Eli Lilly and is also human premixed insulin made up of 30% short-acting insulin and 70% intermediate-acting, isophane insulin.
The only pre-mixed insulin that will be available from Novo Nordisk is NovoMix 30, an analogue premixed insulin 30% of rapid-acting NovoRapid [aspart] insulin and 70% protamine insulin aspart. This is not the same, nor even similar as NovoMix 30 has a very different peak and duration of action to Mixtard 30, as the chart below clearly demonstrates. The chart also demonstrates that Humulin M3 is more similar to Mixtard 30 than NovoMix 30.
So if you are forced to change from Mixtard 30, then the nearest equivalent insulin is Humulin M3. Clearly, Novo Nordisk will want people to stay with their brand of insulin, in this case NovoMix 30, and you may be advised to do this but remember, this is not the same. IDDTâ€™s advice is to discuss your options with your diabetes team and if you want the nearest equivalent insulin, then ask to change to Humulin M3 and not NovoMix 30.Â
Duration of the peak of action of premixed insulins
Information drawn from MIMS, June 2010